No GGS is the most beginner friendly route because you do not need to learn any of the more difficult skips used in Any% such as Green Ghost Skip, Fishy Skip, and Creepy Early. The snack count is also more lenient in No GGS which means you do not need to be as precise in your snack collecting.

Tutorial

Updated Tutorial by Nestani

More in-depth tutorial by Harsh

Comparison

Using older routes, here you can see a general comparison between a GGS and a No GGS run and how much time can be saved by doing the trick. While you need to spend more time collecting snacks throughout the run, you more than make up for it with the time you save from skipping the Green Ghost boss fight and all of the Crypt levels.