There are no universal rules that apply without fail to each and every speedrun, except I guess that the run has to be your own. Ask the community for the specific game you're wondering about.

Absolutely not! Ever had one of those teachers in high school that'd put on a video and then leave the cursor sitting right in the center? That's you!

I didn't fully understand the issue but wouldn't global hotkeys solve the problem?

@DoctorDave5001 most likely

Unacceptable

Even better, there's a magical button called "Capture Mouse Cursor" which can be unticked.

99% of speedrunners don't know this exists.

What? I thought everyone knew.

@Drakodan but what if my game has a built in cursor 🤔

Then nowhere to hide for you.