So I would like to start speed running this game. I looked into the info posted and want to start. But does anyone know if it’s best to run the original or get game off of GOG? Also any ideas on how to skip cutsceans?

You cannot skip cutscenes, however they patched in a speedup key in a later build, which is the one on GOG and Steam.

The speedup button is also usable during normal gameplay, so you can speedup overworld movement, battles, etc.

I've planed to route/run this game for a while now, but haven't really gotten the time and motivation yet.

(Also sorry for responding kind of late, I apparently didn't have notifications on for this game.)

You can actually skip the cutscenes. What you need to do is to press "esc" while running into a cutscene trigger. (You don't stop running while in the menu). When you will hit the trigger the "pause" splash will appear in the menu indicating that a cutscene began. Then you need to save and load the game (still in the menu). After the game will be loaded the cutscene will be skipped. Sometimes after skip the game does weird things like changing fov for example.
One more thing you can do with that glitch: if you'd attempt to skip a battle like that the game will skip every other battle afterwards making it a pacifist run of some sort. Restarting the game brings things back to normal. So you glitch the game, skip all the battles you need, restart when you need normal behavior and then glitch it again once more to keep going.
https://www.youtube.com/watch?v=CNPfA75ScSU
A bit different way to skip battles:
https://www.youtube.com/watch?v=k2QfDqnIq5U
This is for ordinary battles which are not tied to cutscenes. You save before the trigger then run into it while in the menu and when a battle starts you load the save you've made before it. The game will usually softlock (your characters and enemies will remain idle) or crash if you'd attempt to load a save made during a glitched battle.

−75% on GOG right now. Im getting it right now. Gonna start run this game very soon. Peace

[Moved everything to the Guides section](https://www.speedrun.com/Anachronox/guides)

Interesting, when loading a save you have a couple of ticks to interact with things before the map switches (with space key, since mouse cursor is in the menu). Activating elevator for example, keeps a part of UI with buttons on screen when the map finishes loading. Talking to someone prior to switching a map will keep a dialogue window on top for a half a second. 
https://i.imgur.com/2X0c4th.png
Tried pickups and this is what I've got with a random thing:
https://i.imgur.com/KMy1Kok.png
Maybe picking up other items will actually do something.
Using worldskill doesn't seem to do anything (well it seems like it, might be just a different timing).
Currently the most consistent thing to interact with is Stargent Laserblade from Mystech Tunnels, interacting with them in different locations gives different results. For example if it's Rowdy's we're all of a sudden trying to interact with a path corner :D
https://i.imgur.com/oRGVGCP.png
Good to know! :D
https://i.imgur.com/6jOdlON.png
So in theory if we'd be able to find matching combinations between maps it is possible to instantly pickup things? :thinking:
Also the space key does a bit weird things. It is supposed to act in the same way as left mouse button(?) but check this out:
https://www.youtube.com/watch?v=F7IoYO7GH1U
The problem is that it is not really consistent, sometimes it works, sometimes it doesn't. Has something to do with camera angles I suppose.

https://www.youtube.com/watch?v=caitWBX_ClU

https://www.youtube.com/watch?v=zDC-NUwUCdo

https://www.youtube.com/watch?v=vU1brRn0fR8

https://youtu.be/TtDmi75I47U

https://www.youtube.com/watch?v=3pEJG0S9-7o

Some new stuff:

Allows to get past the sock check so you can get a weapon upgrade for Boots earlier or complete Eddie's quest right away:

https://www.youtube.com/watch?v=PCEPerU3KuQ

Dupe of pick-ups. There was a way to dupe equipment prior to that, but that one allows to duplicate all pick-ups (collectibles, cobalt crawlers, quest items) as well as equipment. But it's limited to one copy I think. So 2 for 1 once.

https://www.youtube.com/watch?v=spoIjlpJDVA

Worldskill Clip

We noclip all the way in direction where the worldskill is taking place, pretty neat stuff.

https://www.youtube.com/watch?v=gP0CIVfxQ0c

https://www.youtube.com/watch?v=XkghVHa7tdU

Multiplied damage by mystech if selecting options from 5 to 0 (using keyboard).
https://www.youtube.com/watch?v=ya4QGP8pTsM