Im not sure if it saves time but it at least shortens the dialogue, in the section where you chase reggie while he is pretending to be a conduit if you shoot him while he is threatening the crowd it cancels his dialogue during that section and plays the shorter reaction line, i think it shortens the animation too but im not 100% sure

I’ll definitely have to try it out. I never thought of this

This was already known, hence why it's a part of the WR run and my 2nd place run.