It is very similar to the regular play through and the only real difference is the enemies have more health effectively making it only a harder and longer run. Although, if you want to do it, you might be able to convince a mod to make it a misc category.

Insane mode would be weird to do since a level 99 would have a clear advantage to a level 60 doing insane mode, but if you have an interest in running it then I can add it if you want.

I just dont know