Since most of this segment is consistent you probably already got the fastest possible time give or take a few seconds since you misclicked with the tweezers. Fast baby skip and good RNG on the Angie spawns, solid time

If you're referring to the lycan that bites Ethan's fingers off, you can run around him on the left and grab the boltcutters, which will despawn him. The one in the barn needs to be killed to progress, that one just tanks a lot of damage