I agree with Slime. Quit outs don't change the run drastically, and using them can be both helpful and detrimental, keep in mind that enemies respawn every time you quit out so you can put yourself in very bad situations if you use them poorly. I think they're completely fine, what I'm more worried about are glitches like the one in this video, which could completely trivialize the run. I think these do belong in a different category if they are not patched by the time the game comes out. (I doubt anyone will want to run this version of the game in the future anyway)