Say I've had a run sitting in the que for 4-5 days, but I get a brand new PB, is it possible to replace the old run with the new one in the waiting list?

You can submit a new run and either a mod or you can delete your obsolete run. FOR EVERYONE - Please do not edit your runs with your new pb its messing with the queue list.

I know editing the video link of a run will mess up the queue, but does something small like just editing the message/description also mess with queue position?

Editing the message/description does not, and that’s fine to do. We’ve had some folks editing verified runs, which kicks things back into queue, but it is causing issues at a point where I have had to reject those edited runs and ask for them to create a new submission for new PB’s. If you’ve submitted something and you need to adjust something because you put something in wrong or you want to put in a new description/message, go for it, but if you have a new PB just submit a new run.

Also, I’m going to link you to this post, https://www.speedrun.com/re2remake/thread/qd464/1#rpbru where I explain more about some things in regards to edited runs and new pb’s before old pb’s are being verified.