In the last room (Examination Room), with the PC and both doors, sometimes I can not complete the trigger, it does not react, I do not understand why, do you know Why ? How to avoid that?

Here's an old thread from SDA laink made that explain the softlock in the last room and how to avoid it: https://forum.speeddemosarchive.com/post/penumbra_black_plaguecompleted_83.html#penumbra_black_plaguecompleted_83

(tl;dr - go in front of the last door until the lights turn on and you wont softlock)