I've wanted to do this for a while, but it's such a daunting thing I've been putting it off for ages. I probably won't do it again soon, but you can definitely shave a massive amount of time off.
I had some timer issues about 2 hours in so the splits get a little off, final time should be right still, at least close enough. i doubt this is going to be the kind of run that a second or two makes a difference between people.
A lot of the early game rests on finding thief quickly and unlocking the tavern and hoping you get 2 good drinks. I didn't on this run, but I've spent days trying and just wanted to get at least one finished. Also, about 4 hours in things look like they're going great, but I get cocky and take a nova tower to the face, leaving me with no money back in town. Very nearly quit at that point.
Sub 5 hours RTA would have been nice, but it's not the end of the world. there are a couple of pauses and things in game, but the video is unedited
Final Splits were: Golem 00:13:00 Warden 01:28:16 Wraiths 02:09:31 Watcher 03:21:37 Vampire 04:57:02 Thundersnow 5:09:32