1.) You shouldn't over click, otherwise it'll slow down the whole run, pace yourself, keep it a decent speed and keep that speed or speed up when on a boss since that is the final stretch.

2.) Don't only get weapons, stick with 2-4 and upgrade them, too many will be too big of a horde to deal with, and never get broken uzi, it sucks.

3.) If there is ever a mythical, get it, stopwatch and invincibility are also very powerful if you get them early game and keep upgrading, weird egg make it even better if used on invincibility, talaria isn't needed that much like any other movement ability because movement isn't needed and bosses that need you to move give you talaria for free.

4.) Magic books are really strong for early game so if you see any books and don't like the other options that much, get magic book, mainly good for early game, so i wouldn't recommend magic books for late game.