The flame thrower is the only outside weapon allowed in an only 1 weapon run. Seeing as uroboros 2 is impossible to kill without it unless you use a rocket launcher or 5 mines/ flash launcher strat. Every other boss in the game from irvin to wesker to jill and even excella can be done with just a singular weapon. Since they can be killed with what ever weapon you are using at the time you must kill them without using outside help so no Ltd no turrets no rocket etc.

As for timing method yes it's done igt so you don't have to worry about about inventory. As for making each weapon a run unfortunately no that's not on the cards.

Infinte ammo is allowed also both armours are allowed. Yes the run should be done in NG+ unless you really wanna challenge your self and go for difficulty over speed. As for taking a break by that we mean dying inventory screens you may take a short break but please specify in your submitted run were you took the break and put time stamps. As for coming back to it another day this isant allowed unless you were recording the whole time as the run must be single segment and done in 1 sitting. Of course as previously mentioned in that 1 sitting you can take a shower or go to the toilet or cook and eat food just keep the device and recording going and time stamp the break when submitting

You probably all know by now but still yes Only 1 weapon runs are done mostly on NG+ with infinte ammo. You and either the ai or coop partner must use the same weapon as you so both using hydra or lhawks etc. And the only other weapon allowed in the run is the flame thrower for uroboros 2 seeing as he's impossible without it unless you use a rocket or 5 proximity mines