This guide will show you how to make the game run without having to insert the original CD or mount an ISO. It will actually make the game portable as well, so you can put it on a USB or something.

1. Make a copy of the game's installation folder on your Desktop and open this new folder. It's best to do it this way because of Windows file permission shenanigans.
2. Delete Unwise.exe and M&M's The Lost Formulas.uns. This step isn't necessary, but these files are just for uninstalling the game and aren't required for the game to run.
3. Insert your original CD or mount your ISO and open it in Windows Explorer. Copy the DATA folder from the CD/ISO into the game's folder, saying Yes to merging folders and overwriting any existing files. You can eject your CD/ISO once the copy process is finished.
4. Open Config.EXE and configure the game however you want. It's important to do this now. I'll explain why later.
5. Open the Setup.cfg file in Notepad. You'll see it saying not to edit this file manually.. Yeah, ignore that.
6. Find the line that says "set G_DataPath". Change its value from whatever your CD drive letter is to the value "." (without the quotes).
7. Now make a new line and type the following: set G_NoCDCheck 1
8. Save the changes you made and close Notepad. Try opening the game (MnMs.exe) and see if it works.

NOTE: If you need to use Config.EXE to change anything, you will have to do steps 7 and 8 again because it will remove this line for whatever reason. It will also remove any settings that are set in the in-game Options menu (Picture Quality, Audio settings, Controller settings, etc.)