I play with mouse and keyboard and strafing is very difficult for me, so i only use it for the final boss. A bit of time could be gained with better movement. This is my 20th run (inluding resets and rerouting) and it had terrible RNG. Two sekletons were blocking my way in the pirates hideout and i had no dragon fruit drops from the trees (both of which never happened before).

I couldn't force the game to run in windowed mode, so I had to use it in the background. Any advice on fixing the issue is appreciated. My timing starts when the game fades in after the intro and ends with the fade to black after you kill the final boss.

All in all the time can be easily improved. I didn't to a lot of testing, so i'm not even sure if this is the best route.