There's already a speed run category that is well known in China called "-6" which is short for farm 131 elite monster in a run. This is a well known farming route intend for farming elite moster to upper limit with a good amount of Mora as soon as possible. You can view the route here:

It is not suitable for fix a route, but what I mean is the aim for this kind route is for Mora and Artifacts(which can also convert to Mora). So there could be a index for efficiency of Mora per time before farm to the upper limit of Elite monsters.

Also, constellation affects damage so it make sense to limit the total constellations in a team.

PS: Besides Mora, other item farming could be a category. For example, Crystal Core. Here is a speedrun(not done by me) for 100 Crystal Cores: