Breaks of how long? Do they add to the time? And do we have to leave the game or just leave the game at 4am

Thinking about doing the 100% speedrun, can I have some clarifications before I do it?

If I do it with 2 players, do both need to be recording, or only one.

Do you have to do the prologue, or not since it's kind of just a tutorial.

What do you clarify as 100%ing, just all contacts, missions. or like all types of drugs sold.

Any clarifications will be great. TY