For Reloaded (or any version of Shadow) to run at full 60FPS at all times / have better performance, perform the below.

Graphics -> General:

For newer nvidia cards (GTX 10XX series or newer)

Make sure your Graphics Backend is set to Vulkan or D3D11.

For older cards, OpenGL may perform better.

Shadow has random crashes if using D3D12 in current versions of Dolphin (2412 at time of writing).

Try them all if you have inconsistent framerates.

Graphics -> Enhancements:

Internal Resolution: Any are allowed. The higher you go the better hardware you need. I personally run 3x Native.

Anti Aliasing is None or 2x or 4x MSAA only, SSAA will have issues with some effects. I use None.

Graphics -> Hacks:

Enable everything except Vertex Rounding / VBI Skip (your call if you want those)

GPU Texture Decoding Slider should be set to the Middle option due to bugs in Dolphin

Config -> General:

Uncheck/Disable "Enable Dual Core (speedup)" - This crashes the game a lot, very redundant if you are on hardware newer than 8th gen middle tier CPUs.

Config -> Advanced:

Enable Emulated CPU Clock Override (132 or 150 or 200)

If your CPU can handle it, you want to set a higher CPU clock rate to get a consistent 60 FPS.

A Wii clock rate (150%) is great on 99% of stages, 200% would be ideal for full consistent 60FPS at all times.

If you are on lower end hardware I recommend around 130-135%. That said, default clockspeed is fine if your hardware can't keep up, you'll just have a few 40-50fps sections.

Game Properties (Right Click the Game -> Properties):

Uncheck "Emulate Disc Speed".

This should already be done automatically if you followed the Reloaded Setup Guide and copied GUPR8P.ini to your Dolphin \GameSettings folder.