when after the second car do i start quicksaving and reloading?

Im noticing in peoples runs that in level 3 some enemies spawn for me that dont spawn for others. Any clue as to why? this level just seems impossible, no matter what i do i die to these enemies that apparently dont spawn for others

yeah iv been thinking about running them all but i would also atleast like to attemp any%

Iv been trying to run this game myself but when it comes to chapter 3 i cant get the compatibility mode skip to work for me regarding chapter 3. Im on windows 10 and iv tried multiple compatibility modes. Any advice?