Whilst not very fun to play on, medium graphics quality is optimal I think because even though it locks your FPS to 30, it allows you to jump further when jumping off of a moving platform, which I think is useful somewhere in the run (not sure where exactly, haven't run this game in a while)
I don't believe there any significant flaws in doing this. It doesn't change run times so there's no reason to not do it, really.
I'm fairly sure we've all encountered this glitch in 11. When you arrive at the autoscroller point and try to pick up the cube, it instead of zooming straight towards you it slowly glides towards your hand, for you to not even pick it up correctly. It would be incredibly helpful if someone could shed some light on the reasoning behind this and if there is a way to get around it. Thanks.