Bloodshot saves between 5-10+ minutes depending on your shotgun, id definitely recommend mechanics(swapping mainly,super simple) and route, OOB skips are pretty easy once you learn the path. Bloodwing is also ~2 minutes saved not huge but worth it. Id also recommend joining the discord, it can be a wealth of info and fast answers for questions that are outside of the tutorial vids by funcannon ¤generaly¤.

2. Use all of the keys in the chest in sanctuary or you get the pop up, tutorial messages should be off, uninstall creature dome, creature slaughterdome pack, Collectors edition and collectors edition pack. you will still have guns and relic, but with only one pop up at the start of the run.

Hope it helps!