In some runs, I have seen people restart very quickly when they want to start another attempt. How is it done?

esc -> space

ummmmmmmmmmmmmmmmmmmmm i just press alt f4

Esc goes back to the menu (like when you die). Then space or enter to play new game

esc+space or esc+enter

you just made we full factory reset my computer i can alter my things many ways

Awesome thank you, guys.