New route saves anywhere from 8 to 13 seconds (heavily depending on execution). This was performed with Ji-min. Hee-min runs are untested.
The video comparison demonstrates about a 12 second difference!
The routes diverge right after you pick up the class A extinguisher.
If it's not clear in the video, the glitch involves mounting the fallen stage lighting at 1:05, walking across the beam, then clipping through the wall by running up against it + clicking the electrical fire. After picking up the valve handle, you can trigger the QT event at the door behind you, then click on the oil fire (using a class B extinguisher), and quickly exit out of the action, and run out.
EDIT: Seems this is only possible for Ji-min. Hee-min's collision doesn't let you get close enough to the electrical fire to click it.
EDIT: Guide to position yourself correctly for the skip:
There haven't been any more useful discoveries since this one, I think.
Although there are a couple small things I started doing which I haven't mentioned anywhere:
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Use controller to choose dialogue options With a controller you can just hold down L or R to select dialogue options instantly, which is faster and easier than spamming Q and E on the keyboard. For skipping cutscenes the mouse is still faster though.
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Bind 'backspace' key to another key, and spam it while picking up small items Basically 'backspace' is the only key which lets you exit a menu without accidentally opening it again. This lets you be more clumsy while picking up tiny items like the jacket key in the nurse's office of MB2, or in ji-min runs picking up the key after collecting the blanket. You need to bind it to a key which is easy to reach and spam though.
Other tricks you can check in runs on the leaderboard