It's obvious Any% is the popular category among runners, but I think a run that more completely exhibits the game might be less esoteric and more enticing to newcomers.

So my question is how well would a "complete" run of the game work? With cutscene skips and everything, but without the invincibility, or skipping large portions of the game?

Space Botany runs All Modules Impossible Glitchless. He attempts the two main cutscene skips but it's not really possible to skip anything else without missing out on modules.

In my opinion it's the best category for the game and one of the most entertaining to watch. Something along those lines would be cool. Not sure about all emails since they're basically just flavor and don't affect gameplay, but All Modules is as close to "100%" as you can get really.

Yeah, the idea was "100%ish"

I think this run is pretty good. I'd like to see it adopted a bit more by the community, but that's their prerogative.