Any% may lead to large skips but a quite a bit of time is spent watching cutscenes. 100% may have some tedious moons.

Anything in between, one end or another?

I would say any% honestly. You can skip just about every cutscene in the game, and 100% literally has 3 hours of coin grinding.

I'm guessing you mean all missions

253 might end up being the best middle-ground

exactly...as 70 star for sm64 16 is the most played because its simple and fast but i dont think anyone cares about its wr 1/0 is for the true heroes only 120 includes boring stars so yeah 70 a.k.a. 253 i'd agree :)

253 moon route already looks more interesting and has less downtime than any% one. I wonder how 503 moon route will fare.

After some thought, the boring moons constitute about 15% of the game so I think 503 moons should be more interesting and have even less downtime than 253 moon missions.

I think any% 2-player would look pretty cool once it's optimized

What I like about 253 moon over No Major Skips is that 253 moon lets you choose how many moons to get from which course, so I'm looking forward to the variety that already comes with it, and will hopefully develop further