In the Resident Evil3 tutorials created by wusscake and jakef1891, full screen is selected.

And wolfdnc says that "Run the game FULLSCREEN it will be faster overall specially puzzles.".

On the other hand, supergamer57 says that 320 x 240 resolution is the fastest.

In fact, what is the optimal choice of monitor settings?

as far as i know resolution is preference. you can run windowed but you dont want to have a bunch of other programs running in the background or it will eat cpu. if you run fullscreen it ignores that for the most part. its all preference but windowed has some chance for bad lag

as far as 320x240 i dont know ive never tried it cause my gpu cant go that low