Before playing, Make sure that everyone knows how there main and sub weapons work, especially how the indication bars change their shooting.

One heart handicap should be off. This is because of the respawn system in multiplayer. The level doesn't end until all players are dead, but it takes less time to have everyone die than it does to respawn (5 seconds is a long time.)

For ideal team setups (any%):

2 players - non-boss One person plays matt, the other plays dnl (dry no legs). This way the matt can deal with high dmg targets while the dnl cleans everything else. The matt should be setup with cactus and holy swords, and should be the one who does all the bombing. The dnl should be setup with default costume and bullet hell to maximize the spread dmg.

2 players: boss Both people play matt. He just deals too much damage, and the boss glitch is limited to one orb without movement on multiplayer. One matt should play with default costume instead of cactus juice, both should use holy swords.

For additional players, add a matt with default costume for 3 players, and a dnl that switches to matt with default costume for bosses on 4 players.