I heve ran the game at 2014 but i am rusty now and my runig partner is out of the gmae! are thear new glitches and/or route at all?
There is skill point duping now. If you manage to spend a point right as the host quits or as you're entering an area transition, you will get the skill but keep the point. This isn't consistent enough to change the route at all, but if it happens it could in theory speed the run up a little bit. I think the kick method of invulnerability might be new since then as well, but I'm not certain. If someone is kicked while reviving someone else, the person revived will be invulnerable. This doesn't grant XP like the res method, but it's still used in the run to make the Maya player invulnerable after getting infinite ammo.
As for routing changes, nobody has really done runs of four player since the Bad Maw farm strat became a thing so it hasn't been tested there, but it's faster by a good bit in solo and two player, so it's probably faster in four player as well. My only concern there would be trying to kill four player health/damage cars in the dust with the Lascaux.