Can you give more specifics? I'm going to assume that you're talking purely about making LiveSplit more aesthetically pleasing. Most people choose to use a background image, which is simply a feature provided in the newer versions of LiveSplit, and from there it's just changing the fonts and order of elements in LiveSplit. It's hard to give specific direction without seeing what your LiveSplit window already looks like though.
Just like Drakodan has said it already. Here's also a thread on how to do the Images as backgrounds: http://www.speedrun.com/Talk/thread/xfnau
From there on just use some good colors which are easy to read and some nice fonts and you're done. This is all I can tell you from all "information" you gave to us. If you need help with something, then post it.