I'm new to the community and about to start submitting runs for GB, GBC, GBA games. But I am waiting for a new piece of hardware by a company called Epilogue. They created a cartridge player that plays on a PC but saves and uses the authentic cart. I wanted to ask if I submitted a run using this hardware, would the run be accepted. The company is about to start shipping out their first batch soon, so I don't have it physically yet. But I'll list the website below and hopefully we can figure out if this is acceptable. Thanks!

https://www.epilogue.co/

Check with the communities for games that you want to run. It’ll depend on each one’s specific rules.

It'll probably come down to the precision of the device and how it matches up with actual hardware. But yeah, what @Pear said.

That being said, this thing looks pretty cool. If it wasn't sold out, I might get one for myself.

The site you linked states that mGBA is used as the main means of emulation. mGBA should be fairly accurate, but this is once again a thing decided by leaderboards on an individual basis. There are definitely more accurate ways of emulating GB and GBC games.