What are the optimal settings to use when speed running the game?

I'd recommend running it on simple graphics quality as it locks the FPS to 60. The intended way to play the game.

Whilst not very fun to play on, medium graphics quality is optimal I think because even though it locks your FPS to 30, it allows you to jump further when jumping off of a moving platform, which I think is useful somewhere in the run (not sure where exactly, haven't run this game in a while)