is using packs like over kill allowed?
Yup. They don't provide /that/ much of an advantage over normal weaponry, and certainly none that would impact a speedrun.
But some runs use the rpg, like the runs on diamond store, and those ones rely on the blast radius of the rpg, and I'm not even sure you could do the same strategy with non explosive weapons, because it would take time to shoot, and even half a second could affect the strategy working or not.
Recent runs
Level: Mall Raid
Level: Nightclub
Level: Blood Money
Level: Black Friday
Level: Trick Or Treat