Umm, yeah. It makes it harder so It would be the fastest to use the normal route. If you're talking about the modes like zombie, rage quit and stuff.
@GerogeMac there are actually some skips that are only possible with zombies. Also, ragequit mode has no affect on the gameplay unless you die. @stargames18 The fastest known dimension is Peach Desert, followed by Cosmic for No Major Skips. The fastest for No skips would probably be Either Cybernaut or Default. And Any% can be done in any dimension (i'm pretty sure). Most people run with Peach for NMS and Default for NS. Let me know if you need more help!
game update!!! load times are gone. yippee!! so a lot of runs will get faster and stuff
also, the in game time setting will (probably) be removed from the time settings thing because we dont use it and its a huge inconvenience for mods happy update !