In my personal opinion, the best to speedrun would be:

1- Set Run (Level 50) 2- Classic Run (Level 25) 3- Classic Run (Level 50) 4- Coin Run (1000 coins)

The reasons are: For (1) it can actually be routed and you can grind it. For (2) as the classic run is too rng based and, while it still has a lot of rng, it's easier to get than level 50. For (3) this is the actual challenge and it's actually possible to do (not as some of the other modes). And (4) because it's pretty diferent from other modes and not as difficult.

The rest modes are pretty luck based, insane and difficult. So for me it would be a no thanks...

If you want to run some of the other modes, say it here so we can define the rules

hey Garita, a question not very related to the post but, can we freely change the options? there is one that can speedrun the run like the camera speed at the start of the level, and can u expand the classic seed to be one for 25 levels and one for 50 levels.