Notable improvements:

• Critical headshot on shield guy at "Plaga 3" - similar to the "4-man weave" strat
• New mouse strat at "J.J. Room" + best J.J. RNG

Possible time saves:

• Critical headshot on shield guy at "Hallway"
• Rare RNG at "J.J. Room", which you can pass through without shooting the 2 enemies at the door (though I'm not sure if this is possible with this new strat)
• Rare RNG at "{Plaga 4} Iron Maiden Room", which you can pass through without getting hit