So I'm already on my first run of game, first one was normal playthrough and get 100%, then I got gold medals on every mission, how I'm playing no HUD, dead eye, reticle and auto-aim. After that I should naturally consider speed-running, but the game doesn't grace itself to speedrunners with it being dialogue heavy and unskippable distances

It seems that you really enjoy the game/story since you've been doing multiple playthroughs in different ways, so maybe you would enjoy speedrunning it? I know that one of the things I enjoy a lot about running this game is seeing the story progress over the duration of the run. But speedrunning this game definitely is a big commitment and as you said it has a lot of dialogue and other stuff that makes it a bit of an odd speedgame. But IDK, if you want to spend 15 hours to play through the game then go for it, I enjoy playing through the game and watching the story and characters progress although I often take a month or two break between each run as it of course is a tedious game to speedrun. But you don't have to jump straight into the full run, you could just start with speedrunning the first chapter for example. (or any of the other chapters).

ok i wrote a lot woops