Ths can be optimized a lot. I hope that this run kickstarts optimization in multiplayer speedruns. Using 2 rogues would make this run faster, since with dodging both of us would take less damadge and we would get more crits. Using more buff plants is a great (if a little bit pay-to win) too. One player uses staff of thunder and trekking pole (and peeking in rooms) to get in the right room, and the other one uses the SoT and the one-punch to defeat the final boss. This is (imo) the optimal strat for 2-player.