Getting some lag when I play, was wondering which settings are best to reduce it

What device do you have? And what emulator are you using?

It all depends on what emulator and hardware you're using. If you're using MelonDS, I suggest DraStic as MelonDS is very focused on emulation accuracy, which is resource heavy, but I've tried both emulators and they run the EXACT same, so you're not at risk of emulation inaccuracies if you switch. Also try hardware acceleration if possible, like instead of using a software render for graphics, use OpenGL. Honestly, just getting a DS/3DS with the game is the best way to go since it eliminates all those issues. There's nothing wrong with pointing a webcam at your DS lol