This run can be done easy with a few simple tips.
1) Use the lack of walls to your advantage, try to go through areas that you otherwise could not.
2) Get the telecard.
3) Play the game enough so you know the route trough the sewers. You cant pay the guy at the beginning to guide you.
4) Run from every battle
5) Make sure to buy the Jogging Skor's
6) Buy only one shotgun In Hurrtown, if you grabbed the "sledgehammer" in the arena you will notice it is actually a Remington, the best gun for this run.
7) give the strongest gun to Matias.
goto the slayer concert for alot of EXP, it speeds up the rest of the game and only cost about 10 seconds.
9) Make sure to grab the coke in Hurrtown. Also don't forget to give it to the party manager who talks to you at the beginning of the game.
10) Grab the "SledgeHammer" in the first arena closet. You will get 5800 nuggets which will be all the money you need for the Jogging Skor's and shotgun. All conveniently located in Hurrtown.