Sub-22 with one death. I believe that almost everything in this game is amenable to manipulated, so this is not the end. Will try to improve to sub-21:30.

Emulator: Kega Fusion 3.64 (Апп. Перез. = Hard Reset).

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Under the timer I posted a video of "21:23" segmented run, which was recorded on a BizHawk emulator. It shows all skips and most of current strats. Input display is on. This video can be regarded as a guide :)