There's a glitch allowing infinite use of grenades or EMPs basically meaning enemies have no chance of doing anything in combat if you use it properly. Similar to the IFG glitch in Bayonetta: , , etc.

This is a pretty dead speedgame at the moment but I'd assume everyone agrees runs with that major glitch shouldn't be compared to normal ones in the future. The glitch isn't common knowledge because all players who know about it banned themselves from using it in any kind of runs (the method is still painfully obvious though..)

A japanese player on nicovideo completed a run of God Hard (no DLC, no IGG) in 2:29:03 a couple months ago: http://www.nicovideo.jp/mylist/54992499 split parts because nico is like that. Run without commentary is on another playlist. Godhard can definitely be speedrunned if someone gets into it and that run is massively improvable.

That runner also found a major autoscroller skip saving about 2min & I found a couple smaller ones with the same glitch after.